Albright's Hereditary Osteodystrophy with Extensive Heterotopic Ossification of the Oral and Maxillofacial Region: How Fetuin Research May Help a Seemingly Impossible Condition


Albright's Hereditary Osteodystrophy with Extensive Heterotopic Ossification of the Oral and Maxillofacial Region: How Fetuin Research May Help a Seemingly Impossible Condition FULL TEXT • Marc G. DuVal, DDS • • Sarah Davidson, DDS • • Andrew Ho, DDS • • Rachale Cohen, DDS • • Michael Park, DDS • • Somayeh Nourian, DDS • • Gerald Baker, DDS, MS, FRCD(C) • • George K.B. Sándor , MD, DDS, PhD, FRCD(C), FRCSC, FACS • A b s t r a c t Albright's hereditary osteodystrophy (AHO) is a complex genetic disorder characterized by brachydactyly, gonadotropin resistance, hypothyroidism, pseudohypoparathyroid syndrome and heterotopic ossification. Heterotopic ossification rarely occurs in the maxillofacial region. In this article, we present such a case, describe the etiology, characteristics and treatment of AHO and suggest a potential role of an inhibitor of bone formation such as fetuin in preventing recurrence of aberrant ossification. Reply to this article \| View replies [0]

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